Regulation of Wnt/β-catenin signaling by posttranslational modifications
The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in embryonic development and adult homeostasis; deregulation of the Wnt pathway contributes to the initiation and progression of human diseases including cancer. Despite its importance in human biology and disease, h...
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BioMed Central
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977945/ |
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pubmed-39779452014-04-08 Regulation of Wnt/β-catenin signaling by posttranslational modifications Gao, Chenxi Xiao, Gutian Hu, Jing Review The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in embryonic development and adult homeostasis; deregulation of the Wnt pathway contributes to the initiation and progression of human diseases including cancer. Despite its importance in human biology and disease, how regulation of the Wnt/β-catenin pathway is achieved remains largely undefined. Increasing evidence suggests that post-translational modifications (PTMs) of Wnt pathway components are essential for the activation of the Wnt/β-catenin pathway. PTMs create a highly dynamic relay system that responds to Wnt stimulation without requiring de novo protein synthesis and offer a platform for non-Wnt pathway components to be involved in the regulation of Wnt signaling, hence providing alternative opportunities for targeting the Wnt pathway. This review highlights the current status of PTM-mediated regulation of the Wnt/β-catenin pathway with a focus on factors involved in Wnt-mediated stabilization of β-catenin. BioMed Central 2014-03-04 /pmc/articles/PMC3977945/ /pubmed/24594309 http://dx.doi.org/10.1186/2045-3701-4-13 Text en Copyright © 2014 Gao et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gao, Chenxi Xiao, Gutian Hu, Jing |
| spellingShingle |
Gao, Chenxi Xiao, Gutian Hu, Jing Regulation of Wnt/β-catenin signaling by posttranslational modifications |
| author_facet |
Gao, Chenxi Xiao, Gutian Hu, Jing |
| author_sort |
Gao, Chenxi |
| title |
Regulation of Wnt/β-catenin signaling by posttranslational modifications |
| title_short |
Regulation of Wnt/β-catenin signaling by posttranslational modifications |
| title_full |
Regulation of Wnt/β-catenin signaling by posttranslational modifications |
| title_fullStr |
Regulation of Wnt/β-catenin signaling by posttranslational modifications |
| title_full_unstemmed |
Regulation of Wnt/β-catenin signaling by posttranslational modifications |
| title_sort |
regulation of wnt/β-catenin signaling by posttranslational modifications |
| description |
The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in embryonic development and adult homeostasis; deregulation of the Wnt pathway contributes to the initiation and progression of human diseases including cancer. Despite its importance in human biology and disease, how regulation of the Wnt/β-catenin pathway is achieved remains largely undefined. Increasing evidence suggests that post-translational modifications (PTMs) of Wnt pathway components are essential for the activation of the Wnt/β-catenin pathway. PTMs create a highly dynamic relay system that responds to Wnt stimulation without requiring de novo protein synthesis and offer a platform for non-Wnt pathway components to be involved in the regulation of Wnt signaling, hence providing alternative opportunities for targeting the Wnt pathway. This review highlights the current status of PTM-mediated regulation of the Wnt/β-catenin pathway with a focus on factors involved in Wnt-mediated stabilization of β-catenin. |
| publisher |
BioMed Central |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977945/ |
| _version_ |
1612074938181615616 |