Sequential posttranslational modifications regulate PKC degradation
PKC phosphorylation promotes its sumoylation, which in turn inhibits its ubiquitination and ultimately reduces its degradation via the ubiquitin-proteasome pathway. These findings provide a molecular explanation for the activation-induced down-regulation of PKC proteins.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713141/ |