Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Haem oxygenase (HO)-1/carbon monoxide (CO) protects cancer cells from oxidative stress, but the gas-responsive signalling mechanisms remain unknown. Here we show using metabolomics that CO-sensitive methylation of PFKFB3, an enzyme producing fructose 2,6-bisphosphate (F-2,6-BP), serves as a switch t...

Full description

Bibliographic Details
Main Authors:	Yamamoto, Takehiro, Takano, Naoharu, Ishiwata, Kyoko, Ohmura, Mitsuyo, Nagahata, Yoshiko, Matsuura, Tomomi, Kamata, Aki, Sakamoto, Kyoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Hishiki, Takako, Suematsu, Makoto
Format:	Online
Language:	English
Published:	Nature Pub. Group 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959213/

Similar Items

Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia
by: Takenouchi, Toshiki, et al.
Published: (2015)

Endotoxemia induces an early differential metabolic response in the heart and liver as determined by metabolomic analysis
by: Bateman, RM, et al.
Published: (2008)

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
by: Iizumi, Takuya, et al.
Published: (2016)

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
by: Rodriguez-Rodriguez, P, et al.
Published: (2012)

p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway
by: Franklin, Derek A., et al.
Published: (2016)

Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications
by: Hishiki, Takako, et al.
Published: (2012)

Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt
by: Marini, Cecilia, et al.
Published: (2016)

PFKFB3 Control of Cancer Growth by Responding to Circadian Clock Outputs
by: Chen, Lili, et al.
Published: (2016)

Regulation of the pentose phosphate pathway in cancer
by: Jiang, Peng, et al.
Published: (2014)

Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice
by: Kubo, Akiko, et al.
Published: (2011)

Inhibition of the Carcinogenic Properties of Urethane by Pentose Nucleotides
by: Cowen, P. N.
Published: (1949)

The Pentose Phosphate Pathway Regulates the Circadian Clock
by: Rey, Guillaume, et al.
Published: (2016)

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
by: Stincone, Anna, et al.
Published: (2014)

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
by: Klarer, Alden C, et al.
Published: (2014)

The kinase domain of PFKFB4 is required to stimulate the glucose metabolism and growth of H460 xenografts
by: Clark, J, et al.
Published: (2014)

Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib
by: Telang, Sucheta, et al.
Published: (2014)

Simultaneous inhibition of the estrogen receptor and 6-phosphofructo-2-kinase (PFKFB3) for the treatment of ER+ breast cancer
by: Imbert-Fernandez, Yoannis, et al.
Published: (2014)

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor
by: Chesney, Jason, et al.
Published: (2015)

The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells
by: Cieślar-Pobuda, Artur, et al.
Published: (2015)

Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells
by: Botchlett, Rachel, et al.
Published: (2016)

IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals
by: Kanda, Takehiro, et al.
Published: (2016)

Enzyme characterisation and kinetic modelling of the pentose phosphate pathway in yeast
by: Messiha, Hanan L., et al.
Published: (2014)

Analysis of regulation of pentose utilisation in Aspergillus niger reveals evolutionary adaptations in Eurotiales
by: Battaglia, E., et al.
Published: (2011)

Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
by: Manganelli, Genesia, et al.
Published: (2012)

Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes
by: Bozdech, Zbynek, et al.
Published: (2005)

Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae
by: Subtil, Thorsten, et al.
Published: (2012)

The Thermoanaerobacter Glycobiome Reveals Mechanisms of Pentose and Hexose Co-Utilization in Bacteria
by: Lin, Lu, et al.
Published: (2011)

Astroglial pentose phosphate pathway rates in response to high-glucose environments
by: Takahashi, Shinichi, et al.
Published: (2012)

Identification and Analysis of the Putative Pentose Sugar Efflux Transporters in Escherichia coli
by: Koita, Khushnuma, et al.
Published: (2012)

TAp73 enhances the pentose phosphate pathway and supports cell proliferation
by: Du, Wenjing, et al.
Published: (2013)

Tolerance of pentose utilising yeast to hydrogen peroxide-induced oxidative stress
by: Spencer, Jennifer, et al.
Published: (2014)

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei
by: Kerkhoven, Eduard J., et al.
Published: (2013)

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
by: Ahmad, F, et al.
Published: (2016)

Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production
by: Tan, Zaigao, et al.
Published: (2016)

Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses
by: Foster, Robert W, et al.
Published: (2015)

Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose
by: Chomvong, Kulika, et al.
Published: (2016)

Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
by: Peiró, Concepción, et al.
Published: (2016)

Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway
by: Campbell, Kate, et al.
Published: (2016)

Improving pentose fermentation by preventing ubiquitination of hexose transporters in Saccharomyces cerevisiae
by: Nijland, Jeroen G., et al.
Published: (2016)

Automated Software Analysis of Fetal Movement Recorded during a Pregnant Woman’s Sleep at Home
by: Nishihara, Kyoko, et al.
Published: (2015)