Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Haem oxygenase (HO)-1/carbon monoxide (CO) protects cancer cells from oxidative stress, but the gas-responsive signalling mechanisms remain unknown. Here we show using metabolomics that CO-sensitive methylation of PFKFB3, an enzyme producing fructose 2,6-bisphosphate (F-2,6-BP), serves as a switch t...

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Bibliographic Details
Main Authors: Yamamoto, Takehiro, Takano, Naoharu, Ishiwata, Kyoko, Ohmura, Mitsuyo, Nagahata, Yoshiko, Matsuura, Tomomi, Kamata, Aki, Sakamoto, Kyoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Hishiki, Takako, Suematsu, Makoto
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959213/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959213/

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