Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors
The PKN (protein kinase N) family of Ser/Thr protein kinases regulates a diverse set of cellular functions, such as cell migration and cytoskeletal organization. Inhibition of tumour PKN activity has been explored as an oncology therapeutic approach, with a PKN3-targeted RNAi (RNA interference)-deri...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958129/ |