Light-assisted small molecule screening against protein kinases

High-throughput live-cell screens are intricate elements of systems biology studies and drug discovery pipelines. Here, we demonstrate an optogenetics-assisted method that obviates the addition of chemical activators and reporters, reduces the number of operational steps and increases information co...

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Bibliographic Details
Main Authors: Inglés-Prieto, Álvaro, Reichhart, Eva, Muellner, Markus K., Nowak, Matthias, Nijman, Sebastian M., Grusch, Michael, Janovjak, Harald
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652335/