Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular basis of tumor development and enable testing of new intervention strategies. The inherent complexity of these models, with often multiple modified tumor suppressor gene...

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Bibliographic Details
Main Authors: Huijbers, Ivo J, Bin Ali, Rahmen, Pritchard, Colin, Cozijnsen, Miranda, Kwon, Min-Chul, Proost, Natalie, Song, Ji-Ying, Vries, Hilda, Badhai, Jitendra, Sutherland, Kate, Krimpenfort, Paul, Michalak, Ewa M, Jonkers, Jos, Berns, Anton
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927956/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927956/

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