Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease

Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease

Objective: The purpose of this study was to investigate the effects and pharmacological mechanisms of icariin, which is the main component in the traditional Chinese herb Epimedium, on β-amyloid (Aβ) production in an amyloid precursor protein (APP) transgenic (Tg) mouse model of Alzheimer's dis...

Full description

Bibliographic Details
Main Authors:	Zhang, Lan, Shen, Cong, Chu, Jin, Zhang, Ruyi, Li, Yali, Li, Lin
Format:	Online
Language:	English
Published:	Ivyspring International Publisher 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927130/

Similar Items

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
by: Zhang, Xiaojie, et al.
Published: (2013)

Sorting out the cell biology of Alzheimer’s disease: focus on BACE1 and APP
by: Annaert, Wim
Published: (2012)

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice
by: Li, Song, et al.
Published: (2015)

Palmitoylated APP Forms Dimers, Cleaved by BACE1
by: Bhattacharyya, Raja, et al.
Published: (2016)

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
by: Johannes Steffen, et al.
Published: (2017-06-01)

The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice
by: Rijal Upadhaya, Ajeet, et al.
Published: (2013)

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
by: Neumann, Ulf, et al.
Published: (2015)

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
by: Sadleir, Katherine R, et al.
Published: (2015)

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
by: Zhao, Yonghao, et al.
Published: (2012)

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells
by: Späni, Claudia, et al.
Published: (2015)

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
by: Heneka, Michael T, et al.
Published: (2005)

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice
by: Dickey, Chad A, et al.
Published: (2005)

The Alzheimer Amyloid Precursor Protein (APP) and Fe65, an APP-Binding Protein, Regulate Cell Movement
by: Sabo, Shasta L., et al.
Published: (2001)

Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway
by: Das, Utpal, et al.
Published: (2015)

A Peptide Binding to the β-Site of APP Improves Spatial Memory and Attenuates Aβ Burden in Alzheimer’s Disease Transgenic Mice
by: Yang, Shi-gao, et al.
Published: (2012)

Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice
by: Luo, Gang, et al.
Published: (2016)

LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD)
by: Lincoln, Sarah, et al.
Published: (2013)

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)
by: von Einem, Bjoern, et al.
Published: (2015)

WhatsApp: What an App!
by: Thota, Raghu S., et al.
Published: (2015)

Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
by: Carrera, Iván, et al.
Published: (2013)

BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo
by: Lee, Edward B., et al.
Published: (2005)

Intravenous Delivery of Targeted Liposomes to Amyloid-β Pathology in APP/PSEN1 Transgenic Mice
by: Tanifum, Eric A., et al.
Published: (2012)

Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells
by: Chen, Rong-fu, et al.
Published: (2015)

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage
by: Whitehouse, Isobel J., et al.
Published: (2013)

APP intracellular domain/WAVE1 pathway reduces amyloid β production
by: Ceglia, Ilaria, et al.
Published: (2015)

RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation
by: Dong, Yuanlin, et al.
Published: (2011)

The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer’s disease
by: ZHANG, QIANLIN, et al.
Published: (2013)

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype
by: Whitehouse, Isobel J., et al.
Published: (2016)

Mobile app recommendations: travel apps
by: Kristen Julia, Anderson
Published: (2016)

Mobile app recommendations: fitness apps
by: Kristen Julia, Anderson
Published: (2016)

Upregulation of PGC-1α expression by Alzheimer’s disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP
by: Robinson, Ari, et al.
Published: (2014)

β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice
by: Sudduth, Tiffany L, et al.
Published: (2014)

Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model
by: Liao, Fan, et al.
Published: (2015)

Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates
by: Mulugeta, Ezra, et al.
Published: (2011)

Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
by: Li, Xuying, et al.
Published: (2014)

The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor
by: Youn, Kumju, et al.
Published: (2016)

Immunocytochemical Characterization of Alzheimer’s Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
by: Ivan Carrera, et al.
Published: (2014-03-01)

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
by: Alejandro Ruiz-Riquelme, et al.
Published: (2018-04-01)

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
by: Balakrishnan, Karthikeyan, et al.
Published: (2015)

Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease
by: Li, Jian-ming, et al.
Published: (2016)