Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis

Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis

Photo-activation of psoralen with UVA irradiation, referred to as PUVA, is used in the treatment of proliferative skin disorders. The anti-proliferative effects of PUVA have been largely attributed to psoralen intercalation of DNA, which upon UV treatment, triggers the formation of interstrand DNA c...

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Bibliographic Details
Main Authors: Xia, Wenle, Gooden, David, Liu, Leihua, Zhao, Sumin, Soderblom, Erik J., Toone, Eric J., Beyer, Wayne F., Walder, Harold, Spector, Neil L.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925176/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925176/

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