Pellino Proteins: Novel Players in TLR and IL-1R Signalling

Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) family play important roles in immunity and inflammation. They initiate common intracellular signalling cascades leading to the activation of nuclear factor-κB (NF-κB) and other transcription factors that stimulate the expres...

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Main Authors:	Schauvliege, Reinout, Janssens, Sophie, Beyaert, Rudi
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922352/

id	pubmed-3922352
recordtype	oai_dc
spelling	pubmed-39223522015-04-27 Pellino Proteins: Novel Players in TLR and IL-1R Signalling Schauvliege, Reinout Janssens, Sophie Beyaert, Rudi Reviews Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) family play important roles in immunity and inflammation. They initiate common intracellular signalling cascades leading to the activation of nuclear factor-κB (NF-κB) and other transcription factors that stimulate the expression of a variety of genes that shape an appropriate immune response. TLR/IL-1R signalling involves multiple protein–protein interactions, but the mechanisms that regulate these interactions are still largely unclear. In this context, Pellino proteins have been suggested to function as evolutionary conserved scaffold proteins in TLR/IL-1R signalling. However, recently Pellino proteins were also proposed to function as novel ubiquitin ligases for IL-1R associated kinase 1 (IRAK-1). Here we review our current knowledge on the expression, biological role and mechanism of action of Pellino proteins in TLR/IL-1R-induced signalling. Blackwell Publishing Ltd 2007-05 2007-07-13 /pmc/articles/PMC3922352/ /pubmed/17635639 http://dx.doi.org/10.1111/j.1582-4934.2007.00040.x Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Schauvliege, Reinout Janssens, Sophie Beyaert, Rudi
spellingShingle	Schauvliege, Reinout Janssens, Sophie Beyaert, Rudi Pellino Proteins: Novel Players in TLR and IL-1R Signalling
author_facet	Schauvliege, Reinout Janssens, Sophie Beyaert, Rudi
author_sort	Schauvliege, Reinout
title	Pellino Proteins: Novel Players in TLR and IL-1R Signalling
title_short	Pellino Proteins: Novel Players in TLR and IL-1R Signalling
title_full	Pellino Proteins: Novel Players in TLR and IL-1R Signalling
title_fullStr	Pellino Proteins: Novel Players in TLR and IL-1R Signalling
title_full_unstemmed	Pellino Proteins: Novel Players in TLR and IL-1R Signalling
title_sort	pellino proteins: novel players in tlr and il-1r signalling
description	Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) family play important roles in immunity and inflammation. They initiate common intracellular signalling cascades leading to the activation of nuclear factor-κB (NF-κB) and other transcription factors that stimulate the expression of a variety of genes that shape an appropriate immune response. TLR/IL-1R signalling involves multiple protein–protein interactions, but the mechanisms that regulate these interactions are still largely unclear. In this context, Pellino proteins have been suggested to function as evolutionary conserved scaffold proteins in TLR/IL-1R signalling. However, recently Pellino proteins were also proposed to function as novel ubiquitin ligases for IL-1R associated kinase 1 (IRAK-1). Here we review our current knowledge on the expression, biological role and mechanism of action of Pellino proteins in TLR/IL-1R-induced signalling.
publisher	Blackwell Publishing Ltd
publishDate	2007
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922352/
_version_	1612057741705084928

Pellino Proteins: Novel Players in TLR and IL-1R Signalling

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