Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-β pathway – implication of C-Krox and Sp1

Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-β pathway – implication of C-Krox and Sp1

Despite several investigations, the transcriptional mechanisms which regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either physiological or pathological situations, such as scleroderma, are not completely known. In this study, we determined the effects of both native ic...

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Bibliographic Details
Main Authors: Renard, Emmanuelle, Chadjichristos, Christos, Kypriotou, Magdalini, Beauchef, Gallic, Bordat, Pascal, Dompmartin, Anne, Widom, Russell L, Boumediene, Karim, Pujol, Jean-Pierre, Galéra, Philippe
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2008
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828896/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828896/

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