Plasmodium falciparum Rab5B Is an N-Terminally Myristoylated Rab GTPase That Is Targeted to the Parasite's Plasma and Food Vacuole Membranes

Plasmodium falciparum Rab5B Is an N-Terminally Myristoylated Rab GTPase That Is Targeted to the Parasite's Plasma and Food Vacuole Membranes

Plasmodium falciparum (Pf) has a family of 11 Rab GTPases to regulate its vesicular transport. However, PfRab5B is unique in lacking a C-terminal geranyl-geranylation motif, while having N-terminal palmitoylation and myristoylation motifs. We show that the N-terminal glycine is required for PfRab5B...

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Bibliographic Details
Main Authors: Ezougou, Carinne Ndjembo, Ben-Rached, Fathia, Moss, David K., Lin, Jing-wen, Black, Sally, Knuepfer, Ellen, Green, Judith L., Khan, Shahid M., Mukhopadhyay, Amitabha, Janse, Chris J., Coppens, Isabelle, Yera, Hélène, Holder, Anthony A., Langsley, Gordon
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912013/

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