Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole
Endocytic transport depends on two consecutive Rabs, Vps21 (Rab5 in metazoans) and Ypt7 (Rab7), which bind to effectors on early and late endosomes. This study now shows that inactivation of Vps21 via its GTPase-activating protein (GAP) Msb3 requires both Ypt7 and fusion with the vacuole. The data s...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571306/ |