Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

LINE-1 (L1) retrotransposons are mobile genetic elements comprising ∼17% of the human genome. New L1 insertions can profoundly alter gene function and cause disease, though their significance in cancer remains unclear. Here, we applied enhanced retrotransposon capture sequencing (RC-seq) to 19 hepat...

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Bibliographic Details
Main Authors: Shukla, Ruchi, Upton, Kyle R., Muñoz-Lopez, Martin, Gerhardt, Daniel J., Fisher, Malcolm E., Nguyen, Thu, Brennan, Paul M., Baillie, J. Kenneth, Collino, Agnese, Ghisletti, Serena, Sinha, Shruti, Iannelli, Fabio, Radaelli, Enrico, Dos Santos, Alexandre, Rapoud, Delphine, Guettier, Catherine, Samuel, Didier, Natoli, Gioacchino, Carninci, Piero, Ciccarelli, Francesca D., Garcia-Perez, Jose Luis, Faivre, Jamila, Faulkner, Geoffrey J.
Format: Online
Language:English
Published: Cell Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898742/

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