Disturbing miR-182 and -381 Inhibits BRD7 Transcription and Glioma Growth by Directly Targeting LRRC4
Inactivated LRRC4 has been clinically detected in gliomas, and promoter hypermethylation has been implicated as the mechanism of inactivation in some of those tumors. Our previous researches indicated that LRRC4 is a target gene of miR-381, the interaction of miR-381 and LRRC4 is involved in glioma...
Main Authors: | Tang, Hailin, Wang, Zeyou, Liu, Qing, Liu, Xiaoping, Wu, Minghua, Li, Guiyuan |
---|---|
Format: | Online |
Language: | English |
Published: |
Public Library of Science
2014
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880275/ |
Similar Items
-
MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells
by: Liu, Xiaoping, et al.
Published: (2015) -
The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells
by: Wang, Zeyou, et al.
Published: (2016) -
MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma
by: Zhang, Zuping, et al.
Published: (2011) -
CPEB1, a histone-modified hypomethylated gene, is regulated by miR-101 and involved in cell senescence in glioma
by: Xiaoping, L, et al.
Published: (2013) -
Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors
by: Wang, Zeyou, et al.
Published: (2014)