A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling

A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling

Fms-like tyrosine kinase-3 is a commonly mutated gene in acute myeloid leukemia, with about one-third of patients carrying an internal-tandem duplication of the juxtamembrane domain in the receptor (FLT3-ITD). FLT3-ITD exhibits altered signaling quality, including aberrant activation of STAT5. To id...

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Bibliographic Details
Main Authors: Caldarelli, A, Müller, J P, Paskowski-Rogacz, M, Herrmann, K, Bauer, R, Koch, S, Heninger, A K, Krastev, D, Ding, L, Kasper, S, Fischer, T, Brodhun, M, Böhmer, F-D, Buchholz, F
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865536/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865536/

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