Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry

Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry

Variants within the gene cluster encoding α3, α5, and β4 nicotinic receptor subunits are major risk factors for substance dependence. The strongest impact on risk is associated with variation in the CHRNA5 gene, where at least two mechanisms are at work: amino acid variation and altered mRNA express...

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Main Authors: Wang, Jen-Chyong, Spiegel, Noah, Bertelsen, Sarah, Le, Nhung, McKenna, Nicholas, Budde, John P., Harari, Oscar, Kapoor, Manav, Brooks, Andrew, Hancock, Dana, Tischfield, Jay, Foroud, Tatiana, Bierut, Laura J., Steinbach, Joe Henry, Edenberg, Howard J., Traynor, Bryan J., Goate, Alison M.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841173/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841173/

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