Loss of p53 Attenuates the Contribution of IL-6 Deletion on Suppressed Tumor Progression and Extended Survival in Kras-Driven Murine Lung Cancer

Loss of p53 Attenuates the Contribution of IL-6 Deletion on Suppressed Tumor Progression and Extended Survival in Kras-Driven Murine Lung Cancer

Interleukin-6 (IL-6) is involved in lung cancer tumorigenesis, tumor progression, metastasis, and drug resistance. Previous studies show that blockade of IL-6 signaling can inhibit tumor growth and increase drug sensitivity in mouse models. Clinical trials in non-small cell lung cancer (NSCLC) revea...

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Bibliographic Details
Main Authors: Tan, Xiaohong, Carretero, Julian, Chen, Zhao, Zhang, Jishuai, Wang, Yanxiao, Chen, Jicheng, Li, Xiubin, Ye, Hui, Tang, Chuanhao, Cheng, Xuan, Hou, Ning, Yang, Xiao, Wong, Kwok-Kin
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829911/

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