Liquid chromatographic–mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria☆

Liquid chromatographic–mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria☆

•Acidosis is an important contributor to mortality in patients with severe malaria.•A novel LC–MS method for simultaneous determination of 8 potential small organic acids contributing to acidosis.•Anion exchange SPE coupled with HILIC and ion trap LC–MS was utilized for separation and detection.•Thi...

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Bibliographic Details
Main Authors: Sriboonvorakul, Natthida, Leepipatpiboon, Natchanun, Dondorp, Arjen M., Pouplin, Thomas, White, Nicholas J., Tarning, Joel, Lindegardh, Niklas
Format: Online
Language:English
Published: Elsevier 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827507/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827507/

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