Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models

Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models

Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) binding agent, has proven to be an effective monotherapy for metastatic melanoma and has shown antitumor activity in trials when administered with other therapeutic agents. We hypothesized that the combination of ipilimumab with chemotherapeuti...

Full description

Bibliographic Details
Main Authors: Jure-Kunkel, Maria, Masters, Gregg, Girit, Emel, Dito, Gennaro, Lee, Francis, Hunt, John T., Humphrey, Rachel
Format: Online
Language:English
Published: Springer Berlin Heidelberg 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755230/

Similar Items

Similar Items