Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is a critical negative regulator of immune responses. Uniquely among known inhibitory receptors, its genetic ablation results in a fulminating and fatal lymphoproliferative disorder. This central regulatory role led to the development of antibodie...

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Bibliographic Details
Main Authors: Peggs, Karl S., Quezada, Sergio A., Chambers, Cynthia A., Korman, Alan J., Allison, James P.
Format: Online
Language:English
Published: The Rockefeller University Press 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722174/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722174/

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