MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial protein MAVS. MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferon...

Full description

Bibliographic Details
Main Authors: Liu, Siqi, Chen, Jueqi, Cai, Xin, Wu, Jiaxi, Chen, Xiang, Wu, You-Tong, Sun, Lijun, Chen, Zhijian J
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743401/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743401/

Similar Items