Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Mitochondrial antiviral signaling (MAVS) protein is required for innate immune responses against RNA viruses. In virus-infected cells MAVS forms prion-like aggregates to activate antiviral signaling cascades, but the underlying structural mechanism is unknown. Here we report cryo-electron microscopi...

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Bibliographic Details
Main Authors: Xu, Hui, He, Xiaojing, Zheng, Hui, Huang, Lily J, Hou, Fajian, Yu, Zhiheng, de la Cruz, Michael Jason, Borkowski, Brian, Zhang, Xuewu, Chen, Zhijian J, Jiang, Qiu-Xing
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932521/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932521/

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