Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development. RasGRP1 is important in some cancers and autoimmune diseases but, in contrast to SOS, its regulatory mechanisms are poorly understood. Activating signals lead to the membrane recruitment...

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Bibliographic Details
Main Authors: Iwig, Jeffrey S, Vercoulen, Yvonne, Das, Rahul, Barros, Tiago, Limnander, Andre, Che, Yan, Pelton, Jeffrey G, Wemmer, David E, Roose, Jeroen P, Kuriyan, John
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728621/

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