Stim1, PKCδ and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development
Clonal deletion of autoreactive B cells is crucial to prevent autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterized a previously unrecognized Ca2+-driven Erk activation pathway, which was pro-apoptotic and biochemically distinct from DAG-ind...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623929/ |