Nbn and Atm Cooperate in a Tissue and Developmental Stage-Specific Manner to Prevent Double Strand Breaks and Apoptosis in Developing Brain and Eye

Nbn and Atm Cooperate in a Tissue and Developmental Stage-Specific Manner to Prevent Double Strand Breaks and Apoptosis in Developing Brain and Eye

Nibrin (NBN or NBS1) and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivity, neurological developmental defects and cancer p...

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Bibliographic Details
Main Authors: Rodrigues, Paulo M. G., Grigaravicius, Paulius, Remus, Martina, Cavalheiro, Gabriel R., Gomes, Anielle L., Martins, Mauricio R., Frappart, Lucien, Reuss, David, McKinnon, Peter J., von Deimling, Andreas, Martins, Rodrigo A. P., Frappart, Pierre-Olivier
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728324/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728324/

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