ATM controls meiotic double-strand break formation

In many organisms, developmentally programmed double-strand breaks (DSBs) formed by the SPO11 transesterase initiate meiotic recombination, which promotes pairing and segregation of homologous chromosomes1. Because every chromosome must receive a minimum number of DSBs, attention has focused on fact...

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Bibliographic Details
Main Authors: Lange, Julian, Pan, Jing, Cole, Francesca, Thelen, Michael P., Jasin, Maria, Keeney, Scott
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213282/