BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

BRCA1 deficiency results in impaired Nrf2-mediated antioxidant responses followed by cell death, with estradiol rescuing the effect by inducing Nrf2 stabilization.

Bibliographic Details
Main Authors:	Gorrini, Chiara, Baniasadi, Pegah S., Harris, Isaac S., Silvester, Jennifer, Inoue, Satoshi, Snow, Bryan, Joshi, Purna A., Wakeham, Andrew, Molyneux, Sam D., Martin, Bernard, Bouwman, Peter, Cescon, David W., Elia, Andrew J., Winterton-Perks, Zoe, Cruickshank, Jennifer, Brenner, Dirk, Tseng, Alan, Musgrave, Melinda, Berman, Hal K., Khokha, Rama, Jonkers, Jos, Mak, Tak W., Gauthier, Mona L.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727320/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727320/