Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy

Vectors based on vaccinia virus (VACV), the vaccine used to eradicate smallpox, are currently popular candidates for the vaccination against numerous infectious diseases including malaria and AIDS. Although VACV induces robust cellular and humoral responses, enhancing the safety and efficacy of thes...

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Bibliographic Details
Main Authors: Sumner, Rebecca P., Ren, Hongwei, Smith, Geoffrey L.
Format: Online
Language:English
Published: Society for General Microbiology 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709586/