Carvedilol Decrease IL-1β and TNF-α, Inhibits MMP-2, MMP-9, COX-2, and RANKL Expression, and Up-Regulates OPG in a Rat Model of Periodontitis

Carvedilol Decrease IL-1β and TNF-α, Inhibits MMP-2, MMP-9, COX-2, and RANKL Expression, and Up-Regulates OPG in a Rat Model of Periodontitis

Periodontal diseases are initiated primarily by Gram-negative, tooth-associated microbial biofilms that elicit a host response that causes osseous and soft tissue destruction. Carvedilol is a β-blocker used as a multifunctional neurohormonal antagonist that has been shown to act not only as an anti-...

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Main Authors: de Araújo Júnior, Raimundo Fernandes, Souza, Tatiana Oliveira, de Medeiros, Caroline Addison Xavier, de Souza, Lélia Batista, Freitas, Maria de Lourdes, de Lucena, Hévio Freitas, do Socorro Costa Feitosa Alves, Maria, de Araújo, Aurigena Antunes
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700994/

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