Olmesartan Decreased Levels of IL-1β and TNF-α, Down-Regulated MMP-2, MMP-9, COX-2, RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model

Olmesartan Decreased Levels of IL-1β and TNF-α, Down-Regulated MMP-2, MMP-9, COX-2, RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model

Methotrexate (MTX) is a pro-oxidant compound that depletes dihydrofolate pools and is widely used in the treatment of leukaemia and other malignancies. The efficacy of methotrexate is often limited by mucositis and intestinal injury, which are major causes of morbidity in children and adults. The ai...

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Bibliographic Details
Main Authors: de Araújo Júnior, Raimundo Fernandes, da Silva Reinaldo, Maria Patrícia Oliveira, Brito, Gerly Anne de Castro, Cavalcanti, Pedro de França, Freire, Marco Aurélio de Moura, de Medeiros, Caroline Addison Xavier, de Araújo, Aurigena Antunes
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273993/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273993/

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