Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer

Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer

Cytotoxic CD8 T cells mediate immunity to pathogens and they are able to eliminate malignant cells. Immunity to viruses and bacteria primarily involves CD8 T cells bearing high affinity T cell receptors (TCRs), which are specific to pathogen-derived (non-self) antigens. Given the thorough eliminatio...

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Bibliographic Details
Main Authors: Hebeisen, Michael, Oberle, Susanne G., Presotto, Danilo, Speiser, Daniel E., Zehn, Dietmar, Rufer, Nathalie
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685811/

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