A molecular profile of T-cell exhaustion in cancer
The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,1 similar as in “exhausted” T-cells in chronic infection.2 The data suggest novel drug targets, and show that T-cell exhaustion is reversi...
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| Format: | Online |
| Language: | English |
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Landes Bioscience
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382859/ |