Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic biosynthesis by controlling intracellular levels of its substrate 3-phosphoglycerate (3-PG)...

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Bibliographic Details
Main Authors: Hitosugi, Taro, Zhou, Lu, Fan, Jun, Elf, Shannon, Zhang, Liang, Xie, Jianxin, Wang, Yi, Gu, Ting-Lei, Aleckovic, Masa, LeRoy, Gary, Kang, Yibin, Kang, Hee-Bum, Seo, Jae-Ho, Shan, Changliang, Jin, Peng, Gong, Weimin, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Chen, Georgia Z., Shin, Dong M., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648882/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648882/

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