Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-κB and MAP kinase signaling during bacterial infections, but the role of this immune axis during viral infections has not been addressed. We demonstrate that Nod2−/− and Ripk2−/− mice are hypersusceptible to influenza A virus infection...

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Bibliographic Details
Main Authors: Lupfer, Christopher, Thomas, Paul G., Anand, Paras K., Vogel, Peter, Milasta, Sandra, Martinez, Jennifer, Huang, Gonghua, Green, Maggie, Kundu, Mondira, Chi, Hongbo, Xavier, Ramnik J., Green, Douglas R., Lamkanfi, Mohamed, Dinarello, Charles A., Doherty, Peter C., Kanneganti, Thirumala-Devi
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631456/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631456/

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