Donor DNA Utilization During Gene Targeting with Zinc-Finger Nucleases
Gene targeting is the term commonly applied to experimental gene replacement by homologous recombination (HR). This process is substantially stimulated by a double-strand break (DSB) in the genomic target. Zinc-finger nucleases (ZFNs) are targetable cleavage reagents that provide an effective means...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Genetics Society of America
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618352/ |