Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases

Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases

Studies in NOD mice have provided important insight into the genetics and pathogenesis of type 1 diabetes (T1D). Our goal was to further explore novel methods of genetic manipulation in this mouse model. We tested the feasibility of using zinc-finger nucleases (ZFNs) to knock out a gene directly in...

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Bibliographic Details
Main Authors: Chen, Yi-Guang, Forsberg, Matthew H., Khaja, Shamim, Ciecko, Ashley E., Hessner, Martin J., Geurts, Aron M.
Format: Online
Language:English
Published: American Diabetes Association 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868049/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868049/

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