Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

Tumour-derived mutant p53 proteins promote invasion, in part, by enhancing Rab coupling protein (RCP)-dependent receptor recycling. Here we identified MET as an RCP-binding protein and showed that mutant p53 promoted MET recycling. Mutant p53-expressing cells were more sensitive to hepatocyte growth...

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Bibliographic Details
Main Authors: Muller, P A J, Trinidad, A G, Timpson, P, Morton, J P, Zanivan, S, van den Berghe, P V E, Nixon, C, Karim, S A, Caswell, P T, Noll, J E, Coffill, C R, Lane, D P, Sansom, O J, Neilsen, P M, Norman, J C, Vousden, K H
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592945/

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