Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome
Mutations in the TP53 gene commonly result in the expression of a full-length protein that drives cancer cell invasion and metastasis. Herein, we have deciphered the global landscape of transcriptional regulation by mutant p53 through the application of a panel of isogenic H1299 derivatives with ind...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282078/ |