MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

We previously reported that the G allele of rs3853839 at 3′untranslated region (UTR) of Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 Eastern Asians [P = 6.5×10−10, odds ratio (OR) (95%CI) = 1.27 (1.1...

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Main Authors: Deng, Yun, Zhao, Jian, Sakurai, Daisuke, Kaufman, Kenneth M., Edberg, Jeffrey C., Kimberly, Robert P., Kamen, Diane L., Gilkeson, Gary S., Jacob, Chaim O., Scofield, R. Hal, Langefeld, Carl D., Kelly, Jennifer A., Ramsey-Goldman, Rosalind, Petri, Michelle A., Reveille, John D., Vilá, Luis M., Alarcón, Graciela S., Vyse, Timothy J., Pons-Estel, Bernardo A., Freedman, Barry I., Gaffney, Patrick M., Sivils, Kathy Moser, James, Judith A., Gregersen, Peter K., Anaya, Juan-Manuel, Niewold, Timothy B., Merrill, Joan T., Criswell, Lindsey A., Stevens, Anne M., Boackle, Susan A., Cantor, Rita M., Chen, Weiling, Grossman, Jeniffer M., Hahn, Bevra H., Harley, John B., Alarcόn-Riquelme, Marta E., Brown, Elizabeth E., Tsao, Betty P.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585142/

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