Role of Epigenetics in Chronic Myeloid Leukemia

Role of Epigenetics in Chronic Myeloid Leukemia

The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone es...

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Main Authors: Machova Polakova, Katerina, Koblihova, Jitka, Stopka, Tomas
Format: Online
Language:English
Published: Current Science Inc. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578734/
id pubmed-3578734
recordtype oai_dc
spelling pubmed-35787342013-02-26 Role of Epigenetics in Chronic Myeloid Leukemia Machova Polakova, Katerina Koblihova, Jitka Stopka, Tomas Chronic Leukemias (J Goldman, Section Editor) The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone escape and propagation. Regulatory events at the levels of gene regulation by transcription factors and microRNAs are discussed in the context of CML pathogenesis and therapeutic modalities. Current Science Inc. 2013-01-08 2013-03 /pmc/articles/PMC3578734/ /pubmed/23296408 http://dx.doi.org/10.1007/s11899-012-0152-z Text en © The Author(s) 2013 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Machova Polakova, Katerina
Koblihova, Jitka
Stopka, Tomas
spellingShingle Machova Polakova, Katerina
Koblihova, Jitka
Stopka, Tomas
Role of Epigenetics in Chronic Myeloid Leukemia
author_facet Machova Polakova, Katerina
Koblihova, Jitka
Stopka, Tomas
author_sort Machova Polakova, Katerina
title Role of Epigenetics in Chronic Myeloid Leukemia
title_short Role of Epigenetics in Chronic Myeloid Leukemia
title_full Role of Epigenetics in Chronic Myeloid Leukemia
title_fullStr Role of Epigenetics in Chronic Myeloid Leukemia
title_full_unstemmed Role of Epigenetics in Chronic Myeloid Leukemia
title_sort role of epigenetics in chronic myeloid leukemia
description The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone escape and propagation. Regulatory events at the levels of gene regulation by transcription factors and microRNAs are discussed in the context of CML pathogenesis and therapeutic modalities.
publisher Current Science Inc.
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578734/
_version_ 1611956512355254272

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