Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A

► The environment alters the immune response to an intradermal (i.d.) TB subunit vaccine, Ad85A. ► Ad85A i.d. induces a lung immune response but is less protective against Mtb than intranasal Ad85A. ► Oral administration of environmental mycobacteria reduces Ad85A i.d induced protection. ► In vivo d...

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Main Authors:	Beverley, Peter, Ronan, Edward, Lee, Lianni, Arnold, Isabelle, Bolinger, Beatrice, Powrie, Fiona, Tchilian, Elma
Format:	Online
Language:	English
Published:	Elsevier Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566543/

id	pubmed-3566543
recordtype	oai_dc
spelling	pubmed-35665432013-02-07 Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A Beverley, Peter Ronan, Edward Lee, Lianni Arnold, Isabelle Bolinger, Beatrice Powrie, Fiona Tchilian, Elma Article ► The environment alters the immune response to an intradermal (i.d.) TB subunit vaccine, Ad85A. ► Ad85A i.d. induces a lung immune response but is less protective against Mtb than intranasal Ad85A. ► Oral administration of environmental mycobacteria reduces Ad85A i.d induced protection. ► In vivo depletion of CD25+ regulatory T cells abolishes the effect of oral mycobacteria. Elsevier Science 2013-02-04 /pmc/articles/PMC3566543/ /pubmed/23262169 http://dx.doi.org/10.1016/j.vaccine.2012.12.024 Text en © 2013 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Beverley, Peter Ronan, Edward Lee, Lianni Arnold, Isabelle Bolinger, Beatrice Powrie, Fiona Tchilian, Elma
spellingShingle	Beverley, Peter Ronan, Edward Lee, Lianni Arnold, Isabelle Bolinger, Beatrice Powrie, Fiona Tchilian, Elma Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A
author_facet	Beverley, Peter Ronan, Edward Lee, Lianni Arnold, Isabelle Bolinger, Beatrice Powrie, Fiona Tchilian, Elma
author_sort	Beverley, Peter
title	Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A
title_short	Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A
title_full	Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A
title_fullStr	Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A
title_full_unstemmed	Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A
title_sort	environmental effects on protection against mycobacterium tuberculosis after immunization with ad85a
description	► The environment alters the immune response to an intradermal (i.d.) TB subunit vaccine, Ad85A. ► Ad85A i.d. induces a lung immune response but is less protective against Mtb than intranasal Ad85A. ► Oral administration of environmental mycobacteria reduces Ad85A i.d induced protection. ► In vivo depletion of CD25+ regulatory T cells abolishes the effect of oral mycobacteria.
publisher	Elsevier Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566543/
_version_	1611953196302860288

Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A

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