Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A

► The environment alters the immune response to an intradermal (i.d.) TB subunit vaccine, Ad85A. ► Ad85A i.d. induces a lung immune response but is less protective against Mtb than intranasal Ad85A. ► Oral administration of environmental mycobacteria reduces Ad85A i.d induced protection. ► In vivo d...

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Bibliographic Details
Main Authors: Beverley, Peter, Ronan, Edward, Lee, Lianni, Arnold, Isabelle, Bolinger, Beatrice, Powrie, Fiona, Tchilian, Elma
Format: Online
Language:English
Published: Elsevier Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566543/