Pathogenic prions deviate PrPC signaling in neuronal cells and impair A-beta clearance

Pathogenic prions deviate PrPC signaling in neuronal cells and impair A-beta clearance

The subversion of the normal function exerted by the cellular prion protein (PrPC) in neurons by pathogenic prions is assumed to have a central role in the pathogenesis of transmissible spongiform encephalopathies. Using two murine models of prion infection, the 1C11 neuronal cell line and neurosphe...

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Main Authors: Pradines, E, Hernandez-Rapp, J, Villa-Diaz, A, Dakowski, C, Ardila-Osorio, H, Haik, S, Schneider, B, Launay, J-M, Kellermann, O, Torres, J-M, Mouillet-Richard, S
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563983/

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