Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

Prion diseases are characterised by the accumulation of PrPSc, an abnormally folded isoform of the cellular prion protein (PrPC), in affected tissues. Following peripheral exposure high levels of prion-specific PrPSc accumulate first upon follicular dendritic cells (FDC) in lymphoid tissues before s...

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Bibliographic Details
Main Authors: McCulloch, Laura, Brown, Karen L., Bradford, Barry M., Hopkins, John, Bailey, Mick, Rajewsky, Klaus, Manson, Jean C., Mabbott, Neil A.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228802/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228802/

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