PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
PINK1 activates the HECT-like E3 ubiquitin ligase activity and self-association of Parkin upstream of its translocation to mitochondria and induction of mitophagy.
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549971/ |