In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25+ FoxP3+ T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmune disease in mouse models, suppress allo-specific responses in murine transplant models,...

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Bibliographic Details
Main Authors: Cousens, Leslie P., Najafian, Nader, Mingozzi, Federico, Elyaman, Wassim, Mazer, Bruce, Moise, Leonard, Messitt, Timothy J., Su, Yan, Sayegh, Mohamed, High, Katherine, Khoury, Samia J., Scott, David W., De Groot, Anne S.
Format: Online
Language:English
Published: Springer US 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538121/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538121/

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