Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function

Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function

Cell growth and differentiation are controlled by growth factor receptors coupled to the GTPase Ras. Oncogenic mutations disrupt GTPase activity leading to persistent Ras signaling and cancer progression. Recent evidence indicates that monoubiquitination of Ras leads to Ras activation. Mutation of t...

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Bibliographic Details
Main Authors: Baker, Rachael, Lewis, Steven M., Sasaki, Atsuo T., Wilkerson, Emily M., Locasale, Jason W., Cantley, Lewis C., Kuhlman, Brian, Dohlman, Henrik G., Campbell, Sharon L.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537887/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537887/

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