OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiquitination...

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Bibliographic Details
Main Authors: Baietti, Maria Francesca, Simicek, Michal, Abbasi Asbagh, Layka, Radaelli, Enrico, Lievens, Sam, Crowther, Jonathan, Steklov, Mikhail, Aushev, Vasily N, Martínez García, David, Tavernier, Jan, Sablina, Anna A
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772950/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772950/

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