PI 3-kinase and disease

by Cantley, Lewis C
Published 2012

Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar

by Cantley, Lewis C
Published 2013

PI 3-kinase and disease

by Cantley, Lewis C
Published 2014

Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice

by Shaw, Reuben J., Cantley, Lewis C.
Published 2012

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

by Luo, Ji, Field, Seth J., Lee, Jennifer Y., Engelman, Jeffrey A., Cantley, Lewis C.
Published 2005

Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts

by Le Ma, Cantley, Lewis C., Janmey, Paul A., Kirschner, Marc W.
Published 1998

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

by Lyssiotis, Costas A., Son, Jaekyoung, Cantley, Lewis C., Kimmelman, Alec C.
Published 2013

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase

by Mullarky, Edouard, Lairson, Luke L., Cantley, Lewis C., Lyssiotis, Costas A.
Published 2016

SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells

by Wang, Huan-You, Lin, Wen, Dyck, Jacqueline A., Yeakley, Joanne M., Songyang, Zhou, Cantley, Lewis C., Fu, Xiang-Dong
Published 1998

Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer

by Lien, Evan C., Lyssiotis, Costas A., Juvekar, Ashish, Hu, Hai, Asara, John M., Cantley, Lewis C., Toker, Alex
Published 2016

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis

by Weiner, Orion D, Rentel, Maike C, Ott, Alex, Brown, Glenn E, Jedrychowski, Mark, Yaffe, Michael B, Gygi, Steven P, Cantley, Lewis C, Bourne, Henry R, Kirschner, Marc W
Published 2006

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

by Vieira, Otilia V., Botelho, Roberto J., Rameh, Lucia, Brachmann, Saskia M., Matsuo, Tsuyoshi, Davidson, Howard W., Schreiber, Alan, Backer, Jonathan M., Cantley, Lewis C., Grinstein, Sergio
Published 2001

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

by Locasale, Jason W, Grassian, Alexandra, Beroukhim, Rameen, Meyerson, Matthew, Wagner, Gerhard, Asara, John M, Brugge, Joan S, Vander Heiden, Matthew G, Cantley, Lewis C
Published 2012

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

by Hutti, Jessica E., Porter, Melissa A., Cheely, Adam W., Cantley, Lewis C., Wang, Xiaodong, Kireev, Dmitri, Baldwin, Albert S., Janzen, William P.
Published 2012

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

by Hu, Jie, Locasale, Jason W., Bielas, Jason H., O’Sullivan, Jacintha, Sheahan, Kieran, Cantley, Lewis C., Vander Heiden, Matthew G., Vitkup, Dennis
Published 2013

Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function

by Baker, Rachael, Lewis, Steven M., Sasaki, Atsuo T., Wilkerson, Emily M., Locasale, Jason W., Cantley, Lewis C., Kuhlman, Brian, Dohlman, Henrik G., Campbell, Sharon L.
Published 2012

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

by Yang, Weiwei, Zheng, Yanhua, Xia, Yan, Ji, Haitao, Chen, Xiaomin, Guo, Fang, Lyssiotis, Costas A., Aldape, Kenneth, Cantley, Lewis C., Lu, Zhimin
Published 2012

Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton

by Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas, Albeck, John G, Tolan, Dean R, Asara, John M, Wulf, Gerburg M, Cantley, Lewis C
Published 2014

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast

by Mitra, Prasenjit, Zhang, Yingjie, Rameh, Lucia E., Ivshina, Maria P., McCollum, Dannel, Nunnari, John J., Hendricks, Gregory M., Kerr, Monica L., Field, Seth J., Cantley, Lewis C., Ross, Alonzo H.
Published 2004

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

by Woodroof, Helen I., Pogson, Joe H., Begley, Mike, Cantley, Lewis C., Deak, Maria, Campbell, David G., van Aalten, Daan M. F., Whitworth, Alexander J., Alessi, Dario R., Muqit, Miratul M. K.
Published 2011